International Journal of Pharmaceutical Technology Letters

Vol. 1 No. 1 (2023): Vol 1, Iss 1, Year 2023
Articles

Development and in vitro evaluation of Sitagliptin Phosphate mucoadhesive tablets for NIDDM

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  • Badri Nagarani,
  • Santhosh Kumar Chinnaiyan,
  • Venkata Radha Gadela
Badri Nagarani
Department of Pharmaceutics, Srikrupa Institute of Pharmaceutical Sciences, Vill: Velikatta, Mdl: Kondapak, Dist: Siddipet, Telangana state-502277, India.
Santhosh Kumar Chinnaiyan
Faculty of pharmacy, Karpagam academy of higher education, Eachaanari, Coimbatore-641021, Tamil nadu, India.
Venkata Radha Gadela
Department of Pharmaceutics, GITAM (deemed to be) University, Rushikonda, Visakapatnam-530045, Andhra Pradesh, India.

Published 2023-06-13

Keywords

  • Sitagliptin Phosphate, Methocel-K4M, Mucoadhesive tablets.

How to Cite

Badri Nagarani, Santhosh Kumar Chinnaiyan, & Venkata Radha Gadela. (2023). Development and in vitro evaluation of Sitagliptin Phosphate mucoadhesive tablets for NIDDM. International Journal of Pharmaceutical Technology Letters, 1(1), 72–79. Retrieved from https://ijptl.com/index.php/journal/article/view/12

Abstract

The objective of the present work was to develop an oral mucoadhesive Sitagliptin Phosphate tablet for the sustained-release. The tablets were prepared by the wet Granulation method, using biodegradable mucoadhesive polymer Methocel-K4M at different concentrations. After examining the flow properties of the powder blends the results were found to be within prescribed limits and indicated good flowing property, hence it was subjected to compression. The tablets were evaluated for post-compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, surface pH, in-vitro studies like swelling, mucoadhesive strength, residence time and drug release. Formulation (F3) showed good muco-adhesive strength (17.15g) and maximum drug release of 100 % in 12 h and residence time (6.1 h). The drug content shown 95.43%, surface pH was found to be 6.5. The Sitagliptin Phosphate release effectively controlled for 12 h with Methocel, thus, can be successfully employed for formulating mucoadhesive tablets. Fitting the data to the Zero order and Higuchi equation indicated the mechanism of drug release.

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